P.P.S.

...and so long as we're talking about 
nice-looking-but-hand-tool-friendly picture frames,
how about half-lap joints (with the ends sticking out proud):

https://www.twistedwoodshop.com/projects/2018/4/25/wood-picture-frame-
using-half-lap-joints">https://www.twistedwoodshop.com/projects/2018/4/25/wood-
picture-frame-using-half-lap-joints
(Again, the I'm using the link only because of the pictures.
Not necessarily recommending any of the techniques, etc.)

I don't know anything about how well the art work Darrell
mentioned in his earlier note would work with something like this,
but it can have a nice "rustic" feel to it.  Cherry's nice of course,
but it can also look real pretty with things like pine.

N